N1660
Sigma
Anti-Nicastrin antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
| MDL number: | MFCD03791914 |
Description
| Immunogen | synthetic peptide corresponding to the C-terminus of human nicastrin (amino acids 693-709) conjugated to KLH. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
Properties
| antibody form | IgG fraction of antiserum |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| mol wt | antigen mol wt 110 kDa |
| species reactivity | human |
| application(s) | immunoblotting: 1:1,000 using whole cell extract of human kidney HEK293 cell line stably transfected with human nicastrin |
| microarray: suitable | |
| Gene Information | human ... NCSTN(23385) |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | NWG |
Related Products
References
| reference | Kornilova, A.Y., et al., The initial substrate-binding site of γ-secretase is located on presenilin near the active site. Proc. Natl. Acad. Sci. U. S. A. 102, 3230-3235, (2005) Abstract |
| Haass, C., et al., Nicalin and its binding partner Nomo are novel Nodal signaling antagonists EMBO J. 23, 3041-3050, (2004) Abstract | |
| Jap, B.K., et al., CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer’s disease amyloid β-peptide production. Proc. Natl. Acad. Sci. U. S. A. 102, 7499-7504, (2005) Abstract |
